A K, Lee HG, Aliev G, Perry G: Since oxidative damage is a key phenomenon in Alzheimer’s illness, treatment with antioxidants seems to become a promising method for slowing disease progression. Oxidative harm and Alzheimer’s illness: are antioxidant therapies helpful? Drug News Perspect 2005, 18:13?9. 9. Liu J, Mori A: Oxidative damage hypothesis of stress-associated aging acceleration: neuroprotective effects of all-natural and nutritional antioxidants. Res Commun Biol Psychol Psychiat Neurosci 2006, 31:103?19. 10. Naito Y, Uchiyama K, Yoshikawa T: Oxidative anxiety involvement in diabetic nephropathy and its prevention by astaxanthin. Oxid Anxiety Illness 2006, 21:235?42. 11. Jain SK: Superoxide dismutase overexpression and cellular oxidative damage in diabetes. A commentary overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes. Cost-free Rad Biol Med 2006, 41:1187?190. 12. Beal MF: Mitochondria, oxidative harm, and inflammation in Parkinson’s disease. Ann N Y Acad Sci 2003, 991:120?31. 13. Heinecke JW: Mechanisms of oxidative harm of low density lipoprotein in human atherosclerosis. Curr Opin Lipidol 1997, 8:268?74. 14. Halliwell B: Ways to characterize a biological antioxidant. Free Rad Res Commun 1990, 9:1?two. 15. Halliwell B: Antioxidants: the basic- what they may be and how to evaluate them. Adv Pharmacol 1997, 38:three?0. 16. Volka M, Rhodes CJ, Moncol J, Izakovic M, Mazur M: Free of charge radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006, 160:1?0. 17. Niki E: Assessment of antioxidant capacity in vitro and vivo. No cost Rad Biol Med 2010, 49:503?15.Conclusions This work describes for the initial time the in vitro antioxidant and cytotoxic activity on the rhizomes of Alpinia pahangensis. The rhizomes showed very good antioxidant capacity when evaluated against 5 antioxidant assays. The ethyl acetate fraction showed very good DPPH radical scavenging and superoxide anion scavenging activities whilst the crude methanol extract possessed outstanding lowering energy ability practically comparable to that of your requirements BHA and ascorbic acid, and superior -carotene bleaching activity.Formula of 4-Chloro-6-methoxypyridin-2-amine In contrast, the hexane extract showed great antiproliferative activity against KB and Ca Ski cell lines but weak antioxidant activity.(3-Cyclopropylphenyl)boronic acid In stock It could as a result be concluded that the rhizomes of Alpinia pahangensis possess the potential to become employed as chemopreventive and chemotherapeutic agent and consumption of these rhizomes may possibly present some health added benefits.PMID:24059181 Further investigation around the underlying mechanism accountable for the biological activities ought to be attempted.Abbreviations DPPH: two,2-diphenyl-1-picrylhydrazyl; SOD: Superoxide dismutase; GC-MS: Gas chromatography ass spectrometry; DNA: Deoxyribonucleic acid; GC: Guanine-cytosine; TA: Thymine-adenine; GAE: Gallic acid equivalents; BHA: Butylated hydroxyanisole; WST-1: 2-(4-iodophenyl)-3-(4-nitrophenyl)5-(two,4-disulfophenyl)-2H-tetrazolium.Phang et al. BMC Complementary and Option Medicine 2013, 13:243 http://biomedcentral/1472-6882/13/Page 9 of18. Moure A, Cruz JM, Franco D, Dominguez JM, Sineiro J, Dominguez H, Nunez M, Parajo JC: All-natural antioxidants from residual sources. Meals Chem 2001, 72:145?71. 19. Madsen HL, Bertelsen G: Spices as antioxidants. Trends Meals Sci Technol 1995, six:271?77. 20. Hazra B, Biswas S, Mandal N: Antioxidant and absolutely free radical scavenging activity of Spondias pinnata. BMC Complement Altern Med 2008, 8:63. 21. Ani V, Naidu KA: Antioxidant prospective of b.
