Ts with two levels of spinal stenosis.Conflict of InterestNo potential conflict of interest relevant to this article was reported.
Redox Biology two (2014) 206?Contents lists accessible at ScienceDirectRedox Biologyjournal homepage: elsevier/locate/redoxMini ReviewA overview on the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkersPhilip A. Kramer 1, Saranya Ravi 1, Balu Chacko, Michelle S. Johnson, Victor M. Darley-Usmar nDepartment of Pathology, UAB Mitochondrial Medicine Laboratory, Center at no cost Radical Biology, University of Alabama at Birmingham, Birmingham, AL, USAart ic l e i nf oArticle history: Received 30 December 2013 Accepted 30 December 2013 Offered online ten January 2014 Keyword phrases: Reserve capacity Oxidative strain Metabolic shift Biomarker Leukocytes Plateletsa b s t r a c tThe assessment of metabolic function in cells isolated from human blood for therapy and diagnosis of illness can be a new and crucial location of translational study. It can be now becoming clear that a broad range of pathologies which present clinically with symptoms predominantly in 1 organ, for example the brain or kidney, also modulate mitochondrial energetics in platelets and leukocytes enabling these cells to serve as “the canary in the coal mine” for bioenergetic dysfunction. This opens up the possibility that circulating platelets and leukocytes can sense metabolic strain in individuals and serve as biomarkers of mitochondrial dysfunction in human pathologies which include diabetes, neurodegeneration and cardiovascular disease. Within this overview we’ll describe how the utilization of glycolysis and oxidative phosphorylation differs in platelets and leukocytes and talk about how they are able to be utilized in patient populations.Buy207591-86-4 Considering the fact that it is clear that the metabolic programs in between leukocytes and platelets are fundamentally distinct the measurement of mitochondrial function in distinct cell populations is required for translational research.Buy883-40-9 2014 The Authors.PMID:35670838 Published by Elsevier B.V. All rights reserved.Contents Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Biological functions and metabolic applications of platelets and leukocytes . . . . Leukocytes and platelets as systemic biomarkers of metabolic tension . . . . . . . New approaches to measuring cellular bioenergetics in leukocytes and platelets . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Cellular mitochondrial physiology and glycolysis in platelets and leukocytes . Differential glycolytic and oxidative metabolism in leukocytes and platelets . Future outlook. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Disclosures. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207 .
